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ea0084ps2-06-53 | Hypothyroidism Treatment | ETA2022

Whole-body oxidative stress measured by biomarkers of RNA and DNA damage is higher in hypothyroid women, even after treatment, than in healthy individuals, measured by biomarkers of RNA and DNA damage

R. Riis Kamilla , B. Larsen Camilla , R. Medici Bjarke , Jensen Christian Z. , H. Winter Kristian , L. Larsen Emil , Bronden Andreas , Ellervik Christina , L. la Cour Jeppe , Hegedus Laszlo , H. Brix Thomas , E. Poulsen Henrik , Faber Jens , K. Knop Filip , Nygaard Birte , J. Bonnema Steen

Introduction: Hypothyroidism has been associated with oxidative stress. Urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG), respectively, represent whole-body RNA and DNA oxidation. While these biomarkers have been associated with increased morbidity and mortality in various diseases, they have been only sparsely explored in patients with thyroid disorders.Method: In 45 women with newly diagn...

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Whole-body oxidative stress measured by biomarkers of RNA and DNA damage is higher in hypothyroid women, even after treatment, than in healthy individuals, measured by biomarkers of RNA and DNA damage

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